Journal
JOURNAL OF ANTIBIOTICS
Volume 73, Issue 5, Pages 320-323Publisher
SPRINGERNATURE
DOI: 10.1038/s41429-020-0281-x
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Funding
- Japan Society for the Promotion of Science (JSPS) [16H06449, 19H02898, 19K22291, 19KK0150, 19K07136]
- Takeda Science Foundation
- Institution of Fermentation at Osaka
- Japan Antibiotics Research Association
- Uehara Memorial Foundation
- HOKUTO Bio-chemical Research Foundation
- Grants-in-Aid for Scientific Research [19K07136, 19K22291, 19H02898, 19KK0150] Funding Source: KAKEN
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Chaetomium globosum is a filamentous fungus from which we have previously isolated a series of interesting natural products. Here, we isolated a previously unknown natural product from the culture of C. globosum. Through spectroscopic and crystallographic characterization, we determined the compound to be a new dimerized azaphilone-type product which we termed cochliodone J (1). Furthermore, our investigation into the biological activity of the natural product determined that 1 was cytotoxic to human cervix carcinoma HeLa cells with an IC50 of 17.3 mu M. Lastly, a plausible biosynthetic mechanism for 1 is suggested based on our previous study on the biosynthesis of a closely related compound, cochliodone A (2).
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