4.5 Article

The GSM BPN-15606 as a Potential Candidate for Preventative Therapy in Alzheimer's Disease

Related references

Note: Only part of the references are listed.
Editorial Material Medicine, General & Internal

Lowering of Amyloid-Beta by β-Secretase Inhibitors - Some Informative Failures

David S. Knopman

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Letter Medicine, General & Internal

Preliminary Results of a Trial of Atabecestat in Preclinical Alzheimer's Disease

David Henley et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Article Medicine, General & Internal

Randomized Trial of Verubecestat for Prodromal Alzheimer's Disease

Michael F. Egan et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Review Neurosciences

Alzheimer's Amyloid-beta is an Antimicrobial Peptide: A Review of the Evidence

Maya L. Gosztyla et al.

JOURNAL OF ALZHEIMERS DISEASE (2018)

Article Pharmacology & Pharmacy

Pharmacological and Toxicological Properties of the Potent Oral γ-Secretase Modulator BPN-15606

Steven L. Wagner et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2017)

Article Cell Biology

Astrogliosis

Michael V. Sofroniew

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2015)

Review Biochemistry & Molecular Biology

A fast growing spectrum of biological functions of γ-secretase in development and disease

Nathalie Jurisch-Yaksi et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2013)

Article Clinical Neurology

Differential Relationships of Reactive Astrocytes and Microglia to Fibrillar Amyloid Deposits in Alzheimer Disease

Alberto Serrano-Pozo et al.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2013)

Article Medicine, General & Internal

A Phase 3 Trial of Semagacestat for Treatment of Alzheimer's Disease

Rachelle S. Doody et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

Article Clinical Neurology

Potential Use of γ-Secretase Modulators in the Treatment of Alzheimer Disease

Steven L. Wagner et al.

ARCHIVES OF NEUROLOGY (2012)

Article Medicine, General & Internal

Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease

Randall J. Bateman et al.

NEW ENGLAND JOURNAL OF MEDICINE (2012)

Article Clinical Neurology

Endogenous Amyloid-β is Necessary for Hippocampal Synaptic Plasticity and Memory

Daniela Puzzo et al.

ANNALS OF NEUROLOGY (2011)

Article Medicine, Research & Experimental

Neuropathological Alterations in Alzheimer Disease

Alberto Serrano-Pozo et al.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2011)

Review Biochemistry & Molecular Biology

Inflammation in transgenic mouse models of neurodegenerative disorders

Claudia Schwab et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2010)

Editorial Material Multidisciplinary Sciences

And four equals one: Presenilin takes the γ-secretase role by itself

Christian B. Lessard et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Multidisciplinary Sciences

Activation and intrinsic γ-secretase activity of presenilin 1

Kwangwook Ahn et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Pharmacology & Pharmacy

Begacestat (GSI-953): A Novel, Selective Thiophene Sulfonamide Inhibitor of Amyloid Precursor Protein γ-Secretase for the Treatment of Alzheimer's Disease

Robert L. Martone et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2009)

Review Biochemistry & Molecular Biology

Twenty years of the Alzheimer's disease amyloid hypothesis: A genetic perspective

RE Tanzi et al.

Article Geriatrics & Gerontology

The microglial phagocytic role with specific plaque types in the Alzheimer disease brain

MR D'Andrea et al.

NEUROBIOLOGY OF AGING (2004)

Article Biochemistry & Molecular Biology

The presenilin C-terminus is required for ER-retention, nicastrin-binding and γ-secretase activity

C Kaether et al.

EMBO JOURNAL (2004)

Article Multidisciplinary Sciences

The role of presenilin cofactors in the γ-secretase complex

N Takasugi et al.

NATURE (2003)

Review Physiology

Alzheimer's disease: Genes, proteins, and therapy

DJ Selkoe

PHYSIOLOGICAL REVIEWS (2001)

Article Pathology

Inflammatory responses to amyloidosis in a transgenic mouse model of Alzheimer's disease

Y Matsuoka et al.

AMERICAN JOURNAL OF PATHOLOGY (2001)