Journal
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume 68, Issue 46, Pages 13131-13137Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.0c01240
Keywords
microbiota; anti-obesity; whole grape seed flour; kefir lactic acid bacteria
Funding
- National Research Foundation of Korea (NRF) - Korean government (MSIP) [2018R1A2B6001097]
- National Research Foundation of Korea [2018R1A2B6001097] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Alterations of intestinal microbiota by synbiotic action of pre- and probiotics may confer health benefits to the host. In this study, high-throughput sequencing of 16S rRNA was used to analyze intestinal microbiota in feces, and the relative abundance of intestinal bacteria was correlated with physiological data from a prior study of a synbiotic combination of flavonoid-rich wine grape seed flour (WGF) and two newly isolated kefir lactic acid bacteria (LAB) in diet-induced obese mice. The combination of WGF and LAB enhanced observed operational taxonomic units and Chaol index compared to WGF alone, indicating an increase in the microbial community richness. The combination significantly enhanced abundance of Akkermansia muciniphila and Nocardia coeliaca and their abundance had an inverse relationship with body weight gain and adipose weight. In conclusion, the synbiotic effects of WGF and LAB on improvement of high-fat-diet-induced obesity are strongly linked to remodeling intestinal microbiota.
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