Journal
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume 68, Issue 1, Pages 117-127Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.9b05796
Keywords
Diaphorina citri Kuwayama; quassinoids; Picrasma quassioides; Abamectin; Trolox
Funding
- Natural Science Foundation of China [31800294, 81960634]
- Innovation Fund of the Ministry of Education [IRT_16R15]
- National Key Research and Development Program of China [2018YFD0201500]
- Natural Science Foundation of Guangxi [2018GXNSFBA138006, 2017GXNSFFA198004, 2016GXNSFGA380005]
- BAGUI Young Scholar Program of Guangxi
- Educational Department of Guangxi [2018KY0089]
- State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources [CMEMR2017-A06]
- Guangxi Normal University [2017ZD007]
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Six new quassinoids, named kumulactone F (1), kumulactone G (2), kumulactone H (4), kumulactone I (5), kumulactone J (6), and kumulactone K (7), a pair of undescribed epimers alpha- and beta-nigakihemiacetal G (3), 15 known quassinoids (8-22), and a mixture of the known compounds alpha- and beta-neoquassin (23) were separated from the dried stems of the medical plants Picrasma quassioides. The chemical structures of all of the new compounds were established by spectroscopic data analyses (HR-ESI-MS, 1D and 2D NMR spectroscopy, and electronic circular dichroism (ECD)). Biologically, compounds 9 and 21 showed toxicity toward the Asian citrus psyllid Diaphorina citri Kuwayama with potent activity even equal to that of the positive control (Abamectin), compound 11 exhibited an excellent neuroprotective effect against SH-SYSY cells which were pretreated by H2O2 with potent activity equal to that of the positive control (Trolox), and none of them showed cytotoxic activity toward the HeLa or A549 cell lines (IC50 > 100 mu M).
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