Journal
INTERNATIONAL PSYCHOGERIATRICS
Volume 33, Issue 3, Pages 217-231Publisher
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S1041610220000216
Keywords
dementia; mild cognitive impairment; cognitive rehabilitation; cognitive behavioral therapy; reminiscence therapy; psychosocial intervention; depressive symptoms; MADRS
Funding
- Norwegian Health Association
- Old Age Psychiatry Research Network
- Telemark Hospital Trust
- Vestfold Trust (TeVe)
- Department of Old Age Psychiatry
- Oslo University Hospital
- Civitan Norway Research Foundation of Alzheimer's Disease
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The study evaluated the CORDIAL program and found that this psychosocial intervention effectively reduced depressive symptoms in MCI and dementia patients, with effects persisting for up to 6 months post-intervention.
Objective: To evaluate the feasibility and effectiveness of the CORDIAL program, a psychosocial intervention consisting of cognitive behavioral therapy (CBT), cognitive rehabilitation, and reminiscence to manage depressive symptoms for people with mild cognitive impairment (MCI) or dementia. Design: We conducted a randomized controlled trial, based on a two-group (intervention and control), pre-/post-intervention design. Setting: Participants were recruited from five different old age psychiatry and memory clinics at outpatients' hospitals. Participants: Hundred and ninety-eight people with MCI or early-stage dementia were included. Intervention: The intervention group (n = 100) received 11 individual weekly sessions of the CORDIAL program. This intervention includes elements from CBT, cognitive rehabilitation, and reminiscence therapy. The control group (n = 98) received treatment-as-usual. Measurements: We assessed Montgomery-angstrom sberg Depression Rating Scale (MADRS) (main outcome), Neuropsychiatric Inventory Questionnaire, and Quality of Life in Alzheimer's disease (secondary outcomes) over the course of 4 months and at a 10-month follow-up visit. Results: A linear mixed model demonstrated that the depressive symptoms assessed by MADRS were significantly more reduced in the intervention groups as compared to the control group (p < 0.001). The effect persisted for 6 months after the intervention. No significant differences between groups were found in neuropsychiatric symptoms or quality of life. Conclusion: Our multicomponent intervention, which comprised 11 individual sessions of CBT, cognitive rehabilitation, and reminiscence therapy, reduced depressive symptoms in people with MCI and dementia.
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