Journal
BRITISH JOURNAL OF HAEMATOLOGY
Volume 176, Issue 2, Pages 222-233Publisher
WILEY
DOI: 10.1111/bjh.14401
Keywords
magnetic resonance imaging; whole body; multiple myeloma; bortezomib; treatment response
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Funding
- CRUK/EPSRC from the KCL/UCL Comprehensive Cancer Imaging Centre [C1519/A10331]
- UK EPSRC [EP/I018700/1, EP/H046410/1]
- EPSRC [EP/H046410/1, EP/I018700/1] Funding Source: UKRI
- Cancer Research UK [16463] Funding Source: researchfish
- Engineering and Physical Sciences Research Council [EP/H046410/1, EP/I018700/1] Funding Source: researchfish
- National Institute for Health Research [CL-2007-18-015] Funding Source: researchfish
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Cross-sectional imaging techniques are being increasingly used for disease evaluation in patients with multiple myeloma. Whole body magnetic resonance imaging (WB-MRI) scanning is superior to plain radiography in baseline assessment of patients but changes following treatment have not been systematically explored. We carried out paired WB-MRI scans in 21 newly diagnosed patients prior to, and 8-weeks after, starting chemotherapy, and analysed stringently selected focal lesions (FLs) for parametric changes. A total of 323 FLs were evaluated, median 20 per patient. At 8 weeks, there was a reduction in estimated tumour volume (eTV), and an increase in signal fat fraction (sFF) and apparent diffusion coefficient (ADC) in the group as a whole (P < 0.001). Patients who achieved complete/very good partial response (CR/VGPR) to induction had a significantly greater increase in sFF compared to those achieving <= partial response (PR; P = 0.001). When analysed on a per-patient basis, all patients achieving CR/VGPR had a significant sFF increase in their FL's, in contrast to patients achieving <= PR. sFF changes in patients reaching maximal response within 100 days (fast responders) were greater compared to slow responders (P = 0.001). Receiver Operator Characteristic analysis indicated that sFF changes at 8 weeks were the best biomarker (area under the Curve 0.95) for an inferior response (<= PR). We conclude that early lesional sFF changes may provide important information on depth of response, and are worthy of further prospective study.
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