Journal
INTERNATIONAL JOURNAL OF NANOMEDICINE
Volume 15, Issue -, Pages 1059-1071Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/IJN.S237544
Keywords
aptamer; theranostics; biosensor; biomedical imaging; drug delivery
Funding
- National Natural Science Foundation of China [81673604]
- Scientific Research Foundation of the First Affiliated Hospital of Jinan University, China [2015210, 2017305]
- Medical Science and Technology Foundation of Guangdong Province [2018313, A2016040]
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Aptamers are a class of targeting ligands that bind exclusively to biomarkers of interest. Aptamers have been identified as candidates for the construction of various smart systems for therapy, diagnosis, bioimaging, and drug delivery due to their high target affinity and specificity. Aptamers are accounted as chemical antibodies that can be readily linked to drugs, sensors, signal enhancers, or nanocarriers for functionalization. Use of aptamer-guided medications, especially nanomedicines, has resulted in encouraging outcomes compared to those use of aptamer-free counterparts. This article reviews recent advances in the use of aptamers as targeting ligands for various biomedical and pharmaceutical purposes. Special interests focus on aptamer-based theranostics, biosensing, bioimaging, drug potentiation, and targeted drug delivery.
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