Related references
Note: Only part of the references are listed.Genetic and pharmacological inhibition of acid ceramidase prevents asymmetric cell division by neosis
Shai White-Gilbertson et al.
JOURNAL OF LIPID RESEARCH (2019)
Control of lysosomal TRPML1 channel activity and exosome release by acid ceramidase in mouse podocytes
Guangbi Li et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2019)
Chemotherapy selection pressure alters sphingolipid composition and mitochondrial bioenergetics in resistant HL-60 cells
Li-Pin Kao et al.
JOURNAL OF LIPID RESEARCH (2019)
Hepatic pathology and altered gene transcription in a murine model of acid ceramidase deficiency
Fabian P. S. Yu et al.
LABORATORY INVESTIGATION (2019)
Pathological manifestations of Farber disease in a new mouse model
Nadine Beckmann et al.
BIOLOGICAL CHEMISTRY (2018)
Mechanisms of lysosomal positioning and movement
Birol Cabukusta et al.
TRAFFIC (2018)
Altered lysosome distribution is an early neuropathological event in neurological forms of Gaucher disease
Hila Zigdon et al.
FEBS LETTERS (2017)
Complete Acid Ceramidase ablation prevents cancer-initiating cell formation in melanoma cells
Michele Lai et al.
SCIENTIFIC REPORTS (2017)
Moving and positioning the endolysosomal system
Juan S. Bonifacino et al.
CURRENT OPINION IN CELL BIOLOGY (2017)
Acid Ceramidase Deficiency in Mice Results in a Broad Range of Central Nervous System Abnormalities
Jakub Sikora et al.
AMERICAN JOURNAL OF PATHOLOGY (2017)
An ER-Associated Pathway Defines Endosomal Architecture for Controlled Cargo Transport
Marlieke L. M. Jongsma et al.
CELL (2016)
Endolysosomes Are the Principal Intracellular Sites of Acid Hydrolase Activity
Nicholas A. Bright et al.
CURRENT BIOLOGY (2016)
ASAH1 variant causing a mild SMA phenotype with no myoclonic epilepsy: a clinical, biochemical and molecular study
Massimiliano Filosto et al.
EUROPEAN JOURNAL OF HUMAN GENETICS (2016)
Mechanisms and functions of lysosome positioning
Jing Pu et al.
JOURNAL OF CELL SCIENCE (2016)
A molecular mechanism to regulate lysosome motility for lysosome positioning and tubulation
Xinran Li et al.
NATURE CELL BIOLOGY (2016)
Loss of ceramide synthase 2 activity, necessary for myelin biosynthesis, precedes tau pathology in the cortical pathogenesis of Alzheimer's disease
Timothy A. Couttas et al.
NEUROBIOLOGY OF AGING (2016)
NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice
Hongbo Zhang et al.
SCIENCE (2016)
Obatoclax impairs lysosomal function to block autophagy in cisplatin-sensitive and -resistant esophageal cancer cells
Le Yu et al.
ONCOTARGET (2016)
Spinal muscular atrophy associated with progressive myoclonic epilepsy: A rare condition caused by mutations in ASAH1
Guido Rubboli et al.
EPILEPSIA (2015)
Altered lysosomal positioning affects lysosomal functions in a cellular model of Huntington's disease
Christine Erie et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2015)
Autophagosome dynamics in neurodegeneration at a glance
Yvette C. Wong et al.
JOURNAL OF CELL SCIENCE (2015)
Acid ceramidase deficiency associated with spinal muscular atrophy with progressive myoclonic epilepsy
Joanna J. Gan et al.
NEUROMUSCULAR DISORDERS (2015)
Uniparental disomy as a cause of spinal muscular atrophy and progressive myoclonic epilepsy: Phenotypic homogeneity due to the homozygous c.125C>T mutation in ASAH1
Beatriz G. Giraldez et al.
NEUROMUSCULAR DISORDERS (2015)
Endolysosomal Deficits Augment Mitochondria Pathology in Spinal Motor Neurons of Asymptomatic fALS Mice
Yuxiang Xie et al.
NEURON (2015)
Massive accumulation of luminal protease-deficient axonal lysosomes at Alzheimer's disease amyloid plaques
Swetha Gowrishankar et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
Impairment of Ceramide Synthesis Causes a Novel Progressive Myoclonus Epilepsy
Nicola Vanni et al.
ANNALS OF NEUROLOGY (2014)
Evidence for clinical, genetic and biochemical variability in spinal muscular atrophy with progressive myoclonic epilepsy
D. A. Dyment et al.
CLINICAL GENETICS (2014)
Rho family GTPases: key players in neuronal development neuronal survival, and neurodegeneration
Trisha R. Stankiewicz et al.
FRONTIERS IN CELLULAR NEUROSCIENCE (2014)
Reduced ceramide synthase 2 activity causes progressive myoclonic epilepsy
Mai-Britt Mosbech et al.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2014)
Loss of Function of Glucocerebrosidase GBA2 Is Responsible for Motor Neuron Defects in Hereditary Spastic Paraplegia
Elodie Martin et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2013)
Farber disease: understanding a fatal childhood disorder and dissecting ceramide biology
Mark S. Sands
EMBO MOLECULAR MEDICINE (2013)
Systemic ceramide accumulation leads to severe and varied pathological consequences
Abdulfatah M. Alayoubi et al.
EMBO MOLECULAR MEDICINE (2013)
Cancer-associated lysosomal changes: friends or foes?
T. Kallunki et al.
ONCOGENE (2013)
Spinal Muscular Atrophy Associated with Progressive Myoclonic Epilepsy Is Caused by Mutations in ASAH1
Jie Zhou et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2012)
Cell cycle regulation of Rho signaling pathways
Muriel David et al.
CELL CYCLE (2012)
Neuronal ceroid lipofuscinosis protein CLN3 interacts with motor proteins and modifies location of late endosomal compartments
Kristiina Uusi-Rauva et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2012)
Roles of the Drosophila LRRK2 homolog in Rab7-dependent lysosomal positioning
Mark W. Dodson et al.
HUMAN MOLECULAR GENETICS (2012)
Acid Ceramidase (ASAH1) Is a Global Regulator of Steroidogenic Capacity and Adrenocortical Gene Expression
Natasha C. Lucki et al.
MOLECULAR ENDOCRINOLOGY (2012)
The histone demethylase PHF8 is essential for cytoskeleton dynamics
Elena Asensio-Juan et al.
NUCLEIC ACIDS RESEARCH (2012)
The spinal muscular atrophy disease protein SMN is linked to the rho-kinase pathway via profilin
Anna Noelle et al.
HUMAN MOLECULAR GENETICS (2011)
Lysosomal positioning coordinates cellular nutrient responses
Viktor I. Korolchuk et al.
NATURE CELL BIOLOGY (2011)
Ceramide acyl chain length markedly influences miscibility with palmitoyl sphingomyelin in bilayer membranes
Bodil Westerlund et al.
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS (2010)
A simple fluorogenic method for determination of acid ceramidase activity and diagnosis of Farber disease
Carmen Bedia et al.
JOURNAL OF LIPID RESEARCH (2010)
Ceramide and neurodegeneration: Susceptibility of neurons and oligodendrocytes to cell damage and death
Arundhati Jana et al.
JOURNAL OF THE NEUROLOGICAL SCIENCES (2009)
Neurodegenerative lysosomal disorders - A continuum from development to late age
Ralph A. Nixon et al.
AUTOPHAGY (2008)
Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate
Cungui Mao et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2008)
Membrane domain formation, interdigitation, and morphological alterations induced by the very long chain asymmetric C24:1 ceramide
Sandra N. Pinto et al.
BIOPHYSICAL JOURNAL (2008)
Autophagy in the pathogenesis of disease
Beth Levine et al.
CELL (2008)
Diverse roles of Rho family GTPases in neuronal development, survival, and death
Daniel A. Linseman et al.
FRONTIERS IN BIOSCIENCE-LANDMARK (2008)
Mammalian Rho GTPases:: new insights into their functions from in vivo studies
Sarah J. Heasman et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2008)
Synthesis of a novel ceramide analogue and its use in a high-throughput fluorogenic assay for ceramidases
Carmen Bedia et al.
CHEMBIOCHEM (2007)
Smn depletion alters profilin II expression and leads to upregulation of the RhoA/ROCK pathway and defects in neuronal integrity
Melissa Bowerman et al.
JOURNAL OF MOLECULAR NEUROSCIENCE (2007)
Acid ceramidase and human disease
Jae-Ho Park et al.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2006)
Alsin/Rac1 signaling controls survival and growth of spinal motoneurons
Arnaud Jacquier et al.
ANNALS OF NEUROLOGY (2006)
Rho family GTPase inhibition reveals opposing effects of mitogen-activated protein kinase kinase/extracellular signal-regulated kinase and Janus kinase/signal transducer and activator of transcription signaling cascades on neuronal survival
FA Loucks et al.
JOURNAL OF NEUROCHEMISTRY (2006)
A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen
J Moffat et al.
CELL (2006)
Molecular associations and surface-active properties of short- and long-N-acyl chain ceramides
J Sot et al.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2005)
p21-activated kinase-1 is necessary for depolarization-mediated neuronal survival
K Johnson et al.
JOURNAL OF NEUROSCIENCE RESEARCH (2005)
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
DD Sarbassov et al.
SCIENCE (2005)
Spatial and temporal control of signaling through lipid rafts
T Golub et al.
CURRENT OPINION IN NEUROBIOLOGY (2004)
Evaluation of a continuous quantification method of apoptosis and necrosis in tissue cultures
D Gawlitta et al.
CYTOTECHNOLOGY (2004)
Elevation of the level and activity of acid ceramidase in Alzheimer's disease brain
Y Huang et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2004)
Purification and characterization of recombinant, human acid ceramidase - Catalytic reactions and interactions with acid sphingomyelinase
XX He et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Conditional suppression of cellular genes: Lentivirus vector-mediated drug-inducible RNA interference
M Wiznerowicz et al.
JOURNAL OF VIROLOGY (2003)
Reduced rates of axonal and dendritic growth in embryonic hippocampal neurones cultured from a mouse model of Sandhoff disease
D Pelled et al.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (2003)
Overexpression of ROCK in human breast cancer cells: Evidence that ROCK activity mediates intracellular membrane traffic of lysosomes
Y Nishimura et al.
PATHOLOGY & ONCOLOGY RESEARCH (2003)
Phosphatidylcholine synthesis is elevated in neuronal models of Gaucher disease due to direct activation of CTP:phosphocholine cytidylyltransferase by glucosylceramide
J Bodennec et al.
FASEB JOURNAL (2002)
Lipid rafts in neuronal signaling and function
BA Tsui-Pierchala et al.
TRENDS IN NEUROSCIENCES (2002)
Relative expression software tool (REST©) for group-wise comparison and statistical analysis of relative expression results in real-time PCR -: art. no. e36
MW Pfaffl et al.
NUCLEIC ACIDS RESEARCH (2002)
Membrane restructuring via ceramide results in enhanced solute efflux
LR Montes et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Insertional mutagenesis of the mouse acid ceramidase gene leads to early embryonic lethality in homozygotes and progressive lipid storage disease in heterozygotes
CM Li et al.
GENOMICS (2002)
A role for small GTPase RhoA in regulating intracellular membrane traffic of lysosomes in invasive rat hepatoma cells
Y Nishimura et al.
HISTOCHEMICAL JOURNAL (2002)
Lipid rafts and signal transduction
K Simons et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2000)
Small guanosine triphosphatase Rho/Rho-associated kinase as a novel regulator of intracellular redistribution of lysosomes in invasive tumor cells
Y Nishimura et al.
CELL AND TISSUE RESEARCH (2000)