Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 21, Issue 5, Pages -Publisher
MDPI
DOI: 10.3390/ijms21051673
Keywords
epigenetic modifications; Th17 cells; tumor microenvironment; TIL
Funding
- INSERM, EFS
- Univ. Bourgogne Franche-Comte
- Ligue Contre le Cancer
- Region Bourgogne Franche-Comte (projet d'envergure structurant C-ICI)
- european founds Programme Interreg France-Suisse 2014-2020 (FEDER) - Projet R-TIC
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Th17 cells represent a subset of CD4+ T cells characterized by the master transcription factor ROR gamma t and the production of IL-17. Epigenetic modifications such as post-translational histone modifications and DNA methylation play a key role in Th17 cell differentiation and high plasticity. Th17 cells are highly recruited in many types of cancer and can be associated with good or bad prognosis. Here, we will review the remodeling of the epigenome induced by the tumor microenvironment, which may explain Th17 cell predominance. We will also discuss the promising treatment perspectives of molecules targeting epigenetic enzymes to remodel a Th17-enriched tumor microenvironment.
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