4.7 Review

New Nanotechnologies for the Treatment and Repair of Skin Burns Infections

Journal

Publisher

MDPI
DOI: 10.3390/ijms21020393

Keywords

burn wound infection; antibiotics; wound healing; nanoparticles

Funding

  1. Portuguese Science and Technology Foundation (FCT/MCT)
  2. European Funds (PRODER/COMPETE) [M-ERA-NET/0004/2015-PAIRED, UIDB/04469/2020]
  3. FEDER, under the Partnership Agreement PT2020

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Burn wounds are highly debilitating injuries, with significant morbidity and mortality rates worldwide. In association with the damage of the skin integrity, the risk of infection is increased, posing an obstacle to healing and potentially leading to sepsis. Another limitation against healing is associated with antibiotic resistance mainly due to the use of systemic antibiotics for the treatment of localized infections. Nanotechnology has been successful in finding strategies to incorporate antibiotics in nanoparticles for the treatment of local wounds, thereby avoiding the systemic exposure to the drug. This review focuses on the most recent advances on the use of nanoparticles in wound dressing formulations and in tissue engineering for the treatment of burn wound infections.

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