Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 21, Issue 2, Pages -Publisher
MDPI
DOI: 10.3390/ijms21020509
Keywords
epigenetics; nucleic acids; RNA; DNA; cardiovascular disease; chronic disease; aging; metabolism
Funding
- Italian Ministry of Health
- EU-CardioRNA COST ACTION [CA17129]
- Telethon Foundation [GGP19035A]
- Italian Ministry of Health, Ricerca Finalizzata 2018 [SG-2018-12366446]
- Ricerca Corrente Italian Ministry of Health, Progetto IMMUNHUB Regione Lombardia e progetto di rete cardiovascolare IRCCS
- Italian Ministry of Education, University and Research [PRIN2017S55RXB]
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RNA epigenetics is perhaps the most recent field of interest for translational epigeneticists. RNA modifications create such an extensive network of epigenetically driven combinations whose role in physiology and pathophysiology is still far from being elucidated. Not surprisingly, some of the players determining changes in RNA structure are in common with those involved in DNA and chromatin structure regulation, while other molecules seem very specific to RNA. It is envisaged, then, that new small molecules, acting selectively on RNA epigenetic changes, will be reported soon, opening new therapeutic interventions based on the correction of the RNA epigenetic landscape. In this review, we shall summarize some aspects of RNA epigenetics limited to those in which the potential clinical translatability to cardiovascular disease is emerging.
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