Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 21, Issue 3, Pages -Publisher
MDPI
DOI: 10.3390/ijms21030690
Keywords
nanoparticles; lead oxide; inhalation exposure; toxicity
Funding
- budget of the Ekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers
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Outbred female rats were exposed to inhalation of lead oxide nanoparticle aerosol produced right then and there at a concentration of 1.30 +/- 0.10 mg/m(3) during 5 days for 4 h a day in a nose-only setup. A control group of rats were sham-exposed in parallel under similar conditions. Even this short-time exposure of a relatively low level was associated with nanoparticles retention demonstrable by transmission electron microscopy in the lungs and the olfactory brain. Some impairments were found in the organism's status in the exposed group, some of which might be considered lead-specific toxicological outcomes (in particular, increase in reticulocytes proportion, in delta-aminolevulinic acid (delta-ALA) urine excretion, and the arterial hypertension's development).
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