Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 21, Issue 1, Pages -Publisher
MDPI
DOI: 10.3390/ijms21010358
Keywords
cardiovascular diseases; ischemia; reperfusion injury; miRNA; oxidative stress; transplantation
Funding
- Slovak Research and Development Agency of Ministry of Education, Science, Research, and Sport of the Slovak Republic [APVV-15-0376]
- Scientific Grant Agency of the Ministry of Education, Science, Research, and Sport of the Slovak Republic
- Slovak Academy of Sciences [VEGA 2/0021/15, VEGA 2/0063/18, VEGA 2/0158/19, VEGA 2/0166/17, VEGA 2/0002/20]
- European Union Structural funds [ITMS 26230120009]
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Reactive oxygen species (ROS) are important molecules in the living organisms as a part of many signaling pathways. However, if overproduced, they also play a significant role in the development of cardiovascular diseases, such as arrhythmia, cardiomyopathy, ischemia/reperfusion injury (e.g., myocardial infarction and heart transplantation), and heart failure. As a result of oxidative stress action, apoptosis, hypertrophy, and fibrosis may occur. MicroRNAs (miRNAs) represent important endogenous nucleotides that regulate many biological processes, including those involved in heart damage caused by oxidative stress. Oxidative stress can alter the expression level of many miRNAs. These changes in miRNA expression occur mainly via modulation of nuclear factor erythroid 2-related factor 2 (Nrf2), sirtuins, calcineurin/nuclear factor of activated T cell (NFAT), or nuclear factor kappa B (NF-kappa B) pathways. Up until now, several circulating miRNAs have been reported to be potential biomarkers of ROS-related cardiac diseases, including myocardial infarction, hypertrophy, ischemia/reperfusion, and heart failure, such as miRNA-499, miRNA-199, miRNA-21, miRNA-144, miRNA-208a, miRNA-34a, etc. On the other hand, a lot of studies are aimed at using miRNAs for therapeutic purposes. This review points to the need for studying the role of redox-sensitive miRNAs, to identify more effective biomarkers and develop better therapeutic targets for oxidative-stress-related heart diseases.
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