Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 20, Issue 23, Pages -Publisher
MDPI
DOI: 10.3390/ijms20236097
Keywords
immune cells; cytokines; wound healing; intestine; inflammatory bowel disease
Funding
- National Institutes of Health [K01DK114390]
- American Cancer Society [RSG-18-050-01-NEC]
- University of New Mexico Environmental Health Signature Program and Superfund [P42 ES025589]
- UNM comprehensive cancer center [P30CA118100]
- Dedicated Health Research Funds at the University of New Mexico School of Medicine
- Academic Science Education and Research Training program at the University of New Mexico Health Sciences Center (NIGMS Institutional Research and Academic Career Development Award) [K12-GM088021]
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Intestinal wound healing is a complicated process that not only involves epithelial cells but also immune cells. In this brief review, we will focus on discussing the contribution and regulation of four major immune cell types (neutrophils, macrophages, regulatory T cells, and innate lymphoid cells) and four cytokines (interleukin-10, tumor necrosis factor alpha, interleukin-6, and interleukin-22) to the wound repair process in the gut. Better understanding of these immune factors will be important for developing novel targeted therapy.
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