Journal
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
Volume 91, Issue -, Pages 9-16Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.ijid.2019.10.045
Keywords
Seroprevalence; Dengue symptomatic; Dengue asymptomatic; Colombia
Categories
Funding
- Colciencias (Red de investigacion multidisciplinaria para la prevencion y control de enfermedades transmitidas por vectores Red ETV) [360-211]
- Universidad El Bosque [PCI 2013-457, PCI2014-073]
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Objectives: Colombia is a dengue hyperendemic country; however, the prevalence of antibodies against dengue in the general population including the inhabitants of rural areas is unknown. This study aimed to determine the prevalence of dengue IgM and IgG antibodies in healthy children and adults in urban and rural areas of seven different endemic regions in Colombia between 2013 and 2015. Design or method: Blood samples from healthy volunteers (1,318) were processed by serology (by indirect IgG and capture IgM and IgG ELISA) and molecular tests to detect viral RNA and circulating serotypes. Results: The seroprevalence of IgG for dengue were 85% in children and over 90% for adults. In addition to the high IgM positive rate (14.9%) and secondary recent infection marker rate (capture IgG, 16%), 8.4% of the healthy volunteers were positive for dengue virus (DENV) RNA. Conclusion: This study confirmed the broad and permanent circulation of DENV in Colombia and the high rates of infection and reinfection suffered by its inhabitants. This information can be used by the health authorities to strengthen vector control and vaccine policies and review the algorithms of diagnosis and disease management in children and adults. (c) 2019 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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