Molecularly Imprinted Sensor based on o-phenylenediamine for Electrochemical Detection of Sulfamethoxazole

Molecularly imprinted electrochemical sensor for the detection of sulfamethoxazole was prepared by electropolymerization with sulfamethoxazole as template molecule and o-phenylenediamine as functional monomer. Electrochemical performance of molecularly imprinted sensor was studied by cyclic voltammetry in 0.1 mol/L KCl solution containing 5 mM K3Fe(CN)(6). On the optimal experimental conditions, square wave voltammetry was used to detect sulfamethoxazole. The square wave voltammetric peak current difference of the sensor has a good linear relationship with the concentration of sulfamethoxazole in the range of 0.2 to 1.4 uM, and the detection limit is 0.05 uM. The molecularly imprinted sensor has good selectivity, repeatability and stability.