Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 147, Issue -, Pages 150-159Publisher
ELSEVIER
DOI: 10.1016/j.ijbiomac.2020.01.057
Keywords
Resveratrol; Pickering emulsions; Chitosan/gum Arabic nanoparticles; Topical delivery; Photostability; Biodegradable
Funding
- Associate Laboratory LSRE-LCM - FCT/MCTES (PIDDAC) [UID/EQU/50020/2019]
- Foundation for Science and Technology (FCT, Portugal)
- CIMO through FEDER under Program PT2020 [UID/AGR/00690/2019]
- FCT [PD/BD/135085/2017]
- Fundação para a Ciência e a Tecnologia [PD/BD/135085/2017] Funding Source: FCT
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The surfactant-free nature and higher stability of Pickering emulsions make them preferable solutions over conventional emulsions for skin applications. In this work, Pickering emulsions stabilized by chitosan/gum Arabic (CH/GA) nanoparticles were tested as vehicles for trans-resveratrol topical delivery. Skin absorption was examined ex vivo using Franz diffusion cells and porcine skin. Pickering emulsions allowed higher cutaneous retention and lower permeation of resveratrol, in comparison with a control solution based on a 20% v/v ethanol. The total amount of resveratrol retained in the skin, 24 h after the application, was 11.60% and 10.82% of the applied dose for the tested Pickering emulsion-based formulations prepared with 0.5% and 1.5% w/v CH/GA nanoparticles, respectively. In contrast, resveratrol skin retention from the control solution was only 2.86%. Confocal laser scanning microscopy revealed enhanced skin deposition of Nile Red to deeper layers from the Pickering emulsion-based formulations. Moreover, Pickering emulsions led to trans-resveratrol photostability increase, as measured after exposure to UV for 4 h. These results show that the CH/GA Pickering emulsions are promising solutions for the topical delivery of trans-resveratrol and have the potential to be used as green cosmetic products. (C) 2020 Elsevier B.V. All rights reserved.
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