Journal
INTERNATIONAL IMMUNOPHARMACOLOGY
Volume 79, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.intimp.2019.106090
Keywords
Progranulin; Sepsis; Inflammation; Mechanism
Categories
Funding
- Affiliated Hospital of Southwest Medical University [18057]
- Luzhou-Southwest Medical University applied basic research project [2018LZXNYD-ZK30]
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Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. The mortality rate of in-hospital patients whose conditions are complicated by sepsis remains high in spite of intensive-care treatment, therefore placing a significant financial burden on the health care system. In recent years, progranulin (PGRN), a cysteine-rich secretory protein (CRISP), has been found to play a crucial role in sepsis. PGRN participates in the pathogenesis of sepsis via diverse pathways, including bacterial clearance, cell growth and survival, tissue repair, and the regulation of inflammation. PGRN knockout mice suffer from serious infectious processes, whereas therapeutic administration of recombinant PGRN to such mice enhances bacterial clearance and reduces organ injury and mortality rate. Even though PGRN plays an important role in regulating sepsis, its potential mechanisms have not been completely clarified. In this review, we summarize the most recent research advances in the study of PGRN and its role in sepsis.
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