Journal
INTERNATIONAL IMMUNOPHARMACOLOGY
Volume 80, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.intimp.2020.106202
Keywords
Tubeimoside I; Osteodasts; Nuclear factor-kappa B
Categories
Funding
- Scientific Research Foundation for PhD of Zunyi Medical University [F-871]
- Students Innovation Training Foundation of Zunyi Medical University [20173810, 20173831]
- Students Innovation Training Foundation of Guizhou Province [2018521443]
- Medical Scientific Research Foundation of Guangdong Province of China [A2019006]
- Guangzhou Medical University Student Laboratory Open Project (2018)
- Young innovative talents project of Guangdong Province [2017KQNCX167]
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Type 2 diabetes mellitus is often companied with osteoporosis, a process which involves osteoclast activation. In this study, we found tubeimoside I, a natural compound isolated from the Chinese medicinal herb Bolbostemma paniculatum (Maxim) Franquet (Cucurbitaceae), significantly ameliorated the decrease of bone mass in type 2 diabetes-induced osteoporosis in rats. It appears that tubeimoside I exerts this protecting effect through inhibiting osteoclast formation and function. Futhermore, our study showed that tubeimoside I inhibits NF-kappa B transcriptional activation and degradation of I kappa B alpha. Collectively, our results reveal that tubeimoside I attenuates osteoclastogenesis through down-regulating NF-kappa B signaling pathway, and is a potential candidate for the treatment of bone-destructive diseases like type 2 diabetic osteoporosis.
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