Journal
INTERNATIONAL IMMUNOPHARMACOLOGY
Volume 80, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.intimp.2020.106210
Keywords
JAK/STAT signaling pathway; Negative regulators; JAK/STAT pathway and diseases; JAKs inhibitors and diseases
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Funding
- Postgraduate Tutor Foundation of Harbin Medical University-Daqing [DSJJ2017001]
- National Natural Science Foundation of China [81903763]
- Natural Science Foundation of Heilongjiang Province [YQ2019H005]
- Fundamental Research Funds for the Provincial Universities [2018XN-25, JFWLD201904]
- China Postdoctoral Science Foundation [2019M661312]
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The JAK/STAT signaling pathway is an universally expressed intracellular signal transduction pathway and involved in many crucial biological processes, including cell proliferation, differentiation, apoptosis, and immune regulation. It provides a direct mechanism for extracellular factors-regulated gene expression. Current researches on this pathway have been focusing on the inflammatory and neoplastic diseases and related drug. The mechanism of JAK/STAT signaling is relatively simple. However, the biological consequences of the pathway are complicated due to its crosstalk with other signaling pathways. In addition, there is increasing evidence indicates that the persistent activation of JAK/STAT signaling pathway is closely related to many immune and inflammatory diseases, yet the specific mechanism remains unclear. Therefore, it is necessary to study the detailed mechanisms of JAK/STAT signaling in disease formation to provide critical reference for clinical treatments of the diseases. In this review, we focus on the structure of JAKs and STATs, the JAK/STAT signaling pathway and its negative regulators, the associated diseases, and the JAK inhibitors for the clinical therapy.
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