Journal
INTERNATIONAL HEART JOURNAL
Volume 61, Issue 1, Pages 153-159Publisher
INT HEART JOURNAL ASSOC
DOI: 10.1536/ihj.19-033
Keywords
Platelet parameters; ABCG4; NCEH1; SCARB2
Categories
Funding
- Natural National Scientific Foundation of China [81602407, 81700372]
- Science and Technology Plan of Health Commission of Jiangxi Province [20185210]
- Medical Scientific Research Foundation of Guangdong Province of China [B2019020]
- Department of Science and Technology of Jiangxi province [20171BCD40024]
Ask authors/readers for more resources
A previous study and a gene-annotation enrichment analysis for potential targets of the microRNA miR-202-3p both suggest that this microRNA might be implicated in cardiovascular and metabolic diseases. In the present study, the role of miR-202-3p in the pathogenesis of coronary heart disease (CHD) was explored. We conduct a case-control study to detect the expression levels of miR-202-3p in peripheral blood cells and found that miR-202-3p expression was significantly higher in CHD cases than in controls (P < 0.001). miR-202-3p levels were negatively correlated with platelet distribution width (r = -0.348, P = 0.002) and mean platelet volume (r = -0.29, P = 0.01). Further functional analyses suggested that stimulation with oxidized low-density lipoprotein (ox-LDL) induced miR-202-3p expression, and that this microRNA suppressed the formation of oxLDL-induced macrophage foam cells derived from THP-1 cells in a feedback manner. In addition. miR-202-3p overexpression modulated the expression of several key genes involved in foam cell formation, including that of ABCG4, NCEH1I, and SCARB2. In summary, miR-202-3p was associated with CHD, exerting a protective role against CHD by feedback suppression of ox-LDL-induced macrophage foam cell formation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available