Synthesis of alkyl/aryl linked binuclear silver(I)-N-Heterocyclic carbene complexes and evaluation of their antimicrobial, hemolytic and thrombolytic potential

A new series of N-Heterocyclic carbene based ligands and their silver(I) complexes was obtained and tested in vitro on three bacterial strains (Bacillus subtillis, Bacillus cereus and Macrococcus brunensis) to assess their antibacterial potential. Hemolytic and thrombolytic activities of ligands and complexes on normal mouse erythrocytes were also assessed. In vitro antibacterial study of ligands and complexes revealed that the complexes are relatively more antibiotically active than the ligands. Zones of inhibition and MIC values revealed that B. subtillis is more sensitive to complexes than B. cereus and M. brunensis while reverse is the case for NHC salts. Hemolytic and thrombolytic assays revealed that the compounds are safe to mouse blood for pre-clinical trials.