Journal
INORGANIC CHEMISTRY
Volume 59, Issue 2, Pages 1306-1314Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.inorgchem.9b03017
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Funding
- Ministere de l'Enseignement Superieur et de la Recherche
- Centre National de la Recherche Scientifique (CNRS)
- Conseil Regional de Bourgogne [2015-9205AAO033S04139/BG0003203]
- French Research National Agency (ANR) [SADAM ANR-16-CE07-0015-02]
- Universite de Bourgogne
- Conseil Regional de Bourgogne through the Plan d'Actions Regional pour l'Innovation (PARI)
- European Union through the PO FEDER-FSE Bourgogne
- French Government Grant
- French National Research Agency (ANR) under the program Investissements d'Avenir [ANR-10-EQPX-05-01/IMAPPI Equipex, (tBu)3-NH2]
- GDR AIM
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In this study, an original aza-BODIPY system comprising two Gd3+ complexes has been designed and synthesized for magnetic resonance imaging/optical imaging applications, by functionalization of the boron center. This strategy enabled the obtainment of a positively charged bimodal probe, which displays an increased water solubility, optimized photophysical properties in the near-infrared region, and very promising relaxometric properties. The absorption and emission wavelengths are 705 and 741 nm, respectively, with a quantum yield of around 10% in aqueous media. Moreover, the system does not produce singlet oxygen upon excitation, which would be toxic for tissues. The relaxivity obtained is high at intermediate fields (16.1 mM(-1) s(-1) at 20 MHz and 310 K) and competes with that of bigger or more rigid systems. A full relaxometric and O-17 NMR study and fitting of the data using the Lipari-Szabo approach showed that this high relaxivity can be explained by the size of the system and the presence of some small aggregates. These optimized photophysical and relaxometric properties highlight the potential use of such systems for future bimodal imaging studies.
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