Journal
BRITISH JOURNAL OF CANCER
Volume 115, Issue 12, Pages 1445-1450Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/bjc.2016.354
Keywords
cell of origin; tumour-initiating cell; glioma; glioblastoma; GBM; molecular subtypes; mouse models
Categories
Funding
- Children's Tumor Foundation Young Investigator Award
- NIH T32 [2T32CA124334-06]
- NIH R01 Grant [CA131313-01A1]
- Cancer Prevention and Research Institute of Texas [RP100782]
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The cellular origin of gliomas remains a topic of controversy in cancer research. Advances in neurobiology, molecular genetics, and functional genomics have ushered new insights through exploiting the development of more sophisticated tools to address this question. Diverse distinct cell populations in the adult brain have been reported to give rise to gliomas, although how these studies relate physiologically to mechanisms of spontaneous tumour formation via accumulation of tumour-initiating mutations within a single cell are less well developed. Recent studies in animal models indicate that the lineage of the tumour-initiating cell may contribute to the biological and genomic phenotype of glioblastoma. These results suggest that the cell of origin may not only serve as a source of diversity for these tumours, but may also provide new avenues for improved diagnostics and therapeutic targeting that may prolong the lives of patients.
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