Journal
INDIAN JOURNAL OF PEDIATRICS
Volume 87, Issue 2, Pages 117-121Publisher
SPRINGER INDIA
DOI: 10.1007/s12098-019-03106-z
Keywords
Neonatal sepsis; MDR; Mortality; Morbidity; Financial burden
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The major causes of emergence of multidrug-resistant organisms (MDRO) in neonatal sepsis include empiric antibiotic prescriptions, unregulated use of over-the-counter drugs, high incidence of healthcare associated infections (HAI), lack of awareness about antibiotic stewardship program and under staffing of neonatal intensive care units. In general, mortality due to MDRO sepsis is significantly higher as compared to non MDRO sepsis. Reported morbidities include prolonged use of total parenteral nutrition, need for central venous catheter, invasive ventilation, increased duration of hospital stay and neurologic sequelae.
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