Journal
IMMUNOLOGY AND CELL BIOLOGY
Volume 98, Issue 4, Pages 253-263Publisher
WILEY
DOI: 10.1111/imcb.12312
Keywords
Antibodies; antibody-dependent cellular cytotoxicity; antibody-dependent phagocytosis; Fc receptors; influenza virus; natural killer cells
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Funding
- Australian National Health and Medical Research Council [1052979]
- James Cook University
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In recent years, there has been a renewed interest in utilizing antibody fragment crystallizable (Fc) functions to prevent and control viral infections. The protective and therapeutic potential of Fc-mediated antibody functions have been assessed for some clinically important human viruses, including HIV, hemorrhagic fever viruses and influenza virus. There is mounting evidence that influenza-specific antibodies with Fc-mediated functions, such as antibody-dependent cellular cytotoxicity and antibody-dependent phagocytosis, can aid in the clearance of influenza virus infection. Recent influenza challenge studies and intravenous immunoglobulin G therapy studies in humans suggest a protective role for Fc effector functions in vivo. Broadly reactive influenza antibodies with Fc-mediated functions are prevalent in the human population and could inform the development of a universally protective influenza vaccine or therapy. In this review, we explore the utility of antibodies with Fc-mediated effector functions against viral infections with a focus on influenza virus.
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