Journal
IMMUNOLOGICAL REVIEWS
Volume 293, Issue 1, Pages 8-24Publisher
WILEY
DOI: 10.1111/imr.12830
Keywords
innate; macrophage; malaria; monocyte; plasmodium; training
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Funding
- NCI NIH HHS [T32 CA130807] Funding Source: Medline
- NIAID NIH HHS [K23 AI132644, R01 AI130131] Funding Source: Medline
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Monocytes are innate immune cells essential for host protection against malaria. Upon activation, monocytes function to help reduce parasite burden through phagocytosis, cytokine production, and antigen presentation. However, monocytes have also been implicated in the pathogenesis of severe disease through production of damaging inflammatory cytokines, resulting in systemic inflammation and vascular dysfunction. Understanding the molecular pathways influencing the balance between protection and pathology is critical. In this review, we discuss recent data regarding the role of monocytes in human malaria, including studies of innate sensing of the parasite, immunometabolism, and innate immune training. Knowledge gained from these studies may guide rational development of novel antimalarial therapies and inform vaccine development.
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