Journal
IMMUNITY
Volume 52, Issue 2, Pages 295-+Publisher
CELL PRESS
DOI: 10.1016/j.immuni.2019.12.002
Keywords
-
Categories
Funding
- European Research Council (ERC-CoG) [648145]
- Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) [324392634-TRR 221]
- University of Regensburg (ReForM C program)
- German-Israeli Helmholtz Research School in Cancer Biology
- German Ministry of Research and Education (BMBF) [031L0076A, 01KU1216B]
- European Research Council (ERC) [648145] Funding Source: European Research Council (ERC)
Ask authors/readers for more resources
Specialized regulatory T (Treg) cells accumulate and perform homeostatic and regenerative functions in nonlymphoid tissues. Whether common precursors for nonlymphoid-tissue Treg cells exist and how they differentiate remain elusive. Using transcription factor nuclear factor, interleukin 3 regulated (Nfil3) reporter mice and single-cell RNA-sequencing (scRNA-seq), we identified two precursor stages of interleukin 33 (IL-33) receptor ST2-expressing non lymphoid tissue Treg cells, which resided in the spleen and lymph nodes. Global chromatin profiling of nonlymphoid tissue Treg cells and the two precursor stages revealed a stepwise acquisition of chromatin accessibility and reprogramming toward the nonlymphoid-tissue Treg cell phenotype. Mechanistically, we identified and validated the transcription factor Batf as the driver of the molecular tissue program in the precursors. Understanding this tissue development program will help to harness regenerative properties of tissue Treg cells for therapy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available