Journal
BRITISH JOURNAL OF CANCER
Volume 114, Issue 1, Pages 1-6Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/bjc.2015.410
Keywords
c-Rel; NF-kappa B; cancer; lymphoma; fibrosis
Categories
Funding
- Leukemia Lymphoma Research grant [11022]
- Cancer Research UK grant [C1443/A12750]
- MRC
- NIHR Newcastle Biomedical Research Centre
- Cancer Research UK [12750] Funding Source: researchfish
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When the genes encoding NF-kappa B subunits were first isolated, their homology to the previously identified c-Rel proto-oncogene and its viral homologue v-Rel was clear. This provided the first indication that these transcription factors also had a role in cancer. Because of its homology to v-Rel, which transforms chicken B cells together with the important role c-Rel can have as a regulator of B- and T-cell proliferation, most attention has focussed on its role in B-cell lymphomas, where the REL gene is frequently amplified. However, a growing number of reports now indicate that c-Rel has important functions in many solid tumours, although studies in mice suggest it may not always function as an oncogene. Moreover, c-Rel is a critical regulator of fibrosis, which provides an environment for tumour development in many settings. Overall, c-Rel is emerging as a complex regulator of tumorigenesis, and there is still much to learn about its functions in human malignancies and the response to cancer therapies.
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