Journal
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
Volume 67, Issue 1, Pages 131-135Publisher
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/TUFFC.2019.2939190
Keywords
Temperature measurement; Temperature sensors; Viscosity; Coagulation; Liquids; Plasma temperature; Acoustic waves; AlN; lamb waves; resonator; temperature monitorable
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Funding
- National Natural Science Foundation of China [51605060]
- National Key Research and Development Program of China [2016YFB0402702]
- Fundamental Research Funds for the Central Universities [2018CDPTCG0001-5]
- Chongqing Basic Science and Frontier Technology Research Project [cstc2017jcyjAX0237]
- Thousands Talents Program for the pioneer researcher and his innovation team, China
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In this study, we reported an acoustic wave resonator for temperature monitorable kinetic analysis of human blood coagulation. The resonator is operated in both Lamb wave mode at 860 MHz and Rayleigh wave mode at 444 MHz. The electrical parameter variation of the resonator induced by the increased plasma viscosity can be used to monitor the coagulation process. The Lamb mode of the resonator is sensitive to both plasma viscosity and plasma temperature, while the Rayleigh mode responds only to the temperature which is not affected by viscosity. These unique characteristics of the two modes are due to different spatial distributions of the acoustic energy. Taking advantage of the aforementioned features, an acoustic wave resonator to study the human blood coagulation is designed to simultaneously monitor the temperature and plasma viscosity. The coagulation time and plasma temperature were provided by fitting the time-frequency curves. Our design holds great promise for biological reaction monitoring with possible temperature changes.
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