Journal
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
Volume 67, Issue 1, Pages 16-26Publisher
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/TBME.2019.2907460
Keywords
Fluorescence tomography; finite element modeling; image reconstruction; optimization; validation
Categories
Funding
- University of Zurich
- BRIDGE proof-of-concept fellowship [178262]
- EU H2020 FET Open project SENSITIVE [801347]
- Spanish Ministry of Economy and Competitiveness [FIS2016-77892-R]
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Objective: Fluorescence molecular tomography (FMT) can provide valuable molecular information by mapping the bio-distribution of fluorescent reporter molecules in the intact organism. Various prototype FMT systems have been introduced during the past decade. However, none of them has evolved as a standard tool for routine biomedical research. The goal of this paper is to develop a software package that can automate the complete FMT reconstruction procedure. Methods: We present smart toolkit for fluorescence tomography (STIFT), a comprehensive platform comprising three major protocols: 1) virtual FMT, i.e., forward modeling and reconstruction of simulated data; 2) control of actual FMT data acquisition; and 3) reconstruction of experimental FMT data. Results: Both simulation and phantom experiments have shown robust reconstruction results for homogeneous and heterogeneous tissue-mimicking phantoms containing fluorescent inclusions. Conclusion: STIFT can be used for optimization of FMT experiments, in particular for optimizing illumination patterns. Significance: This paper facilitates FMT experiments by bridging the gaps between simulation, actual experiments, and data reconstruction.
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