Journal
HUMAN GENETICS
Volume 139, Issue 6-7, Pages 1011-1022Publisher
SPRINGER
DOI: 10.1007/s00439-020-02141-7
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Funding
- St. Giles Foundation
- Rockefeller University
- INSERM, Paris University, HHMI
- French National Research Agency (ANR) under the Investissement d'avenir program [ANR-10-IAHU-01]
- LTh-MSMD-CMCD project [ANR-18-CE93-0008-01]
- HGDIFD project [ANR-14-CE15-0006-01]
- EURO-CMC project [ANR-14-RARE-0005-02]
- NIH [R01 AI127564-01]
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Candida species, including C. albicans in particular, can cause superficial or invasive disease, often in patients with known acquired immunodeficiencies or iatrogenic conditions. The molecular and cellular basis of these infections in patients with such risk factors remained largely elusive, until the study of inborn errors of immunity clarified the basis of the corresponding inherited and idiopathic infections. Superficial candidiasis, also known as chronic mucocutaneous candidiasis (CMC), can be caused by inborn errors of IL-17 immunity. Invasive candidiasis can be caused by inborn errors of CARD9 immunity. In this chapter, we review both groups of inborn errors of immunity, and discuss the contribution of these studies to the deciphering of the critical mechanisms of anti-Candida immunity in patients with other conditions.
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