Journal
HEARING RESEARCH
Volume 399, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.heares.2020.107936
Keywords
Animal model; Auditory cortex; Mismatch negativity; Schizophrenia; Stimulus-specific adaptation
Funding
- JSPS KAKENHI [JP17K20090, JP18H04999, JP18K18138]
- AMED [JP19dm0307009]
- NEDO [18101806-0]
- Tateisi Science and Technology Foundation
- Nakatani Foundation for the Advancement of Measuring Technologies in Biomedical Engineering [2017S013]
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Research comparing the electrophysiological, pharmacological, and functional properties of mismatch negativity (MMN)-like responses and adaptation-exhibiting middle-latency responses (MLRs) in animals and humans found clear differences between them. The study also demonstrated that MMN-like responses represent empirical salience of deviant stimuli, suggesting a new functional role of MMN beyond simple deviance detection.
Mismatch negativity (MMN) has long been considered to be one of the deviance-detecting neural characteristics. Animal models exhibit similar neural activities, called MMN-like responses; however, there has been considerable debate on whether MMN-like responses are homologous to MMN in humans. Herein, we reviewed several studies that compared the electrophysiological, pharmacological, and functional properties of MMN-like responses and adaptation-exhibiting middle-latency responses (MLRs) in animals with those in humans. Accumulating evidence suggests that there are clear differences between MMN-like responses and MLRs, in particular that MMN-like responses can be distinguished from mere effects of adaptation, i.e., stimulus-specific adaptation. Finally, we discuss a new direction for research on MMN-like responses by introducing our recent work, which demonstrated that MMN-like responses represent empirical salience of deviant stimuli, suggesting a new functional role of MMN beyond simple deviance detection. (C) 2020 Elsevier B.V. All rights reserved.
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