Journal
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
Volume 42, Issue 5, Pages 1067-1076Publisher
WILEY
DOI: 10.1002/hed.26104
Keywords
biomarkers; EMT-TFs; HNSCC; meta-analysis; prognosis
Categories
Funding
- Fundamental Research Funds for the Central Universities [11ykpy47]
- National Natural Science Foundation of China [81572661, 81202136]
- Natural Science Foundation of Guangdong Province [2017A030313515]
- Pear River S&T Nova Program of Guangzhou [2014J2200045]
- Specialized Research Fund for the Doctoral Program of Higher Education [20120171120068]
- Sun Yat-Sen University Clinical Research 5010 Program [2015018]
- National Key Research and Development Program of China [2016YFC0902700]
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Epithelial-mesenchymal transition (EMT) plays a critical role in cancer progression and is primarily regulated by several EMT-inducing transcription factors (EMT-TFs), including TWIST1, TWIST2, SNAI1, SNAI2, ZEB1, and ZEB2. However, the prognostic value of EMT-TFs remains controversial in head and neck squamous cell carcinoma (HNSCC). Studies on the prognostic role of EMT-TFs in HNSCC were searched for in the Web of Science, Science Direct, Proquest, EMBASE, PubMed, and Cochrane Library. Meta-analysis was performed by using Revman 5.2 software. The pooled analysis showed that overexpression of EMT-TFs indicated a poor overall survival (OS) (HR = 1.93, 95% CI = 1.67-2.23) of HNSCC. Subgroup analysis for individual EMT-TFs revealed that overexpression of TWIST1 (HR = 1.61, 95% CI = 1.29-2.02), SNAI1 (HR = 2.17, 95% CI = 1.63-2.88), SNAI2 (HR = 1.90, 95% CI = 1.38-2.62), and ZEB1 (HR = 2.70, 95% CI = 1.61-4.53) were significantly associated with poor OS of HNSCC. These findings support the hypothesis that overexpression of EMT-TFs indicates a poor prognosis for HNSCC patients.
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