Journal
GYNECOLOGICAL ENDOCRINOLOGY
Volume 36, Issue 7, Pages 657-659Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/09513590.2019.1707178
Keywords
Random-start; ovarian stimulation; GnRH agonist trigger; OHSS; pregnancy
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We report the first case of OHSS following GnRH agonist trigger for final follicular maturation in random start ovarian stimulation for egg-donation cycles during inadvertent concomitant early pregnancy. As an additional note, the sustained activity exerted by the increasing endogenous hCG production seemed to be responsible for the suboptimal performance in terms of oocyte yield in the current case. OHSS can occur in random-start stimulations protocols even after the use of a GnRH agonist for triggering in case of concomitant unnoticed early pregnancy especially if stimulation is commenced in the periovulatory/luteal phase. The present case report introduces a note of extreme caution when proceeding with this protocol in an otherwise fertile population (egg-donors, elective or oncologic oocyte cryopreservation).
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