Journal
GERONTOLOGY
Volume 66, Issue 3, Pages 275-285Publisher
KARGER
DOI: 10.1159/000504962
Keywords
alpha-Glycerophosphocholine; Antiaging effects; Gene expression; Cognitive function; Taste sensitivity; beta-oxidation
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Funding
- Japan Society for the Promotion of Science [16H03045, 19H02905]
- Kieikai Research Foundation [2018S026]
- Council for Science, Technology and Innovation (CSTI), Cross-ministerial Strategic Innovation Promotion Program (SIP) [14532924]
- Grants-in-Aid for Scientific Research [19H02905, 16H03045] Funding Source: KAKEN
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alpha-Glycerophosphocholine (GPC) is a natural source of choline. It reportedly prevents aging-related decline in cognitive function, but the underlying mechanism remains unclear. Although it is understood that aging influences taste sensitivity and energy regulation, whether GPC exerts antiaging effects on such phenomena requires further elucidation. Here, we used old C57BL/6J mice that were fed a GPC-containing diet, to investigate the molecular mechanisms underlying the prevention of a decline in cognitive function associated with aging and examine the beneficial effects of GPC intake on aging-related phenomena, such as taste sensitivity and energy regulation. We confirmed that GPC intake reduces the aging-related decline in the expression levels of genes related to long-term potentiation. Although we did not observe an improvement in aging-related decline in taste sensitivity, there was a notable improvement in the expression levels of beta-oxidation-associated genes in old mice. Our results suggest that the prevention of aging-related decline in cognitive function by GPC intake may be associated with the improvement of gene expression levels of long-term potentiation. Furthermore, GPC intake may positively influence lipid metabolism.
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