Journal
GENES & DEVELOPMENT
Volume 34, Issue 5-6, Pages 321-340Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.334284.119
Keywords
PARP; ARTD; adipocyte; adipogenesis; mitochondria; lipolysis; differentiation; white adipocytes; brown adipocytes; beige adipocytes; stem cell; PARylation; high fat diet; obesity; insulin resistance; AFLD; NAFLD; atherosclerosis
Categories
Funding
- Nemzeti Kutatasi, Fejlesztesi es Innovacios Hivatal (NKFIH) [K123975, PD121138, GINOP-2.3.2-15-2016-00006]
- Hungarian Academy of Sciences [NKM-26/2019]
- Higher Education Institutional Excellence Program of the Ministry of Innovation and Technology in Hungary of the University of Debrecen [NKFIH-1150-6/2019]
Ask authors/readers for more resources
Poly(ADP-ribose) polymerases (PARPs or ARTDs), originally described as DNA repair factors, have metabolic regulatory roles. PARP1, PARP2, PARP7, PARP10, and PARP14 regulate central and peripheral carbohydrate and lipid metabolism and often channel pathological disruptive metabolic signals. PARP1 and PARP2 are crucial for adipocyte differentiation, including the commitment toward white, brown, or beige adipose tissue lineages, as well as the regulation of lipid accumulation. Through regulating adipocyte function and organismal energy balance, PARPs play a role in obesity and the consequences of obesity. These findings can be translated into humans, as evidenced by studies on identical twins and SNPs affecting PARP activity.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
