Journal
GENE
Volume 724, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.gene.2019.144146
Keywords
miR-214; MKK3; Cervical cancer; Proliferation; Migration; Invasion
Categories
Funding
- Youth Incubation Foundation of TMUGH [ZYYFY2015021]
- Science and Technology Foundation of Tianjin Municipal Health Bureau [2015KZ115]
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miRNA mediated genetic regulation is widely involved in carcinogenesis of cervical cancer. In this study, miR-214 was confirmed to directly regulate MKK3 via imperfect base-pairing to its 3'UTR, resulting down-regulation of its expression level. Compared to normal tissues, a down-regulated level of miR-214 was observed in cervical cancer, while MKK3 was up-regulated. Next, we demonstrated that over-expression of miR-214 or knockdown of MKK3 can inhibit the growth, proliferation, invasion and migration of cervical cancer in vitro and in vivo. Moreover, the effects of miR-214 in HeLa cells were rescued by the restoration of MKK3. In conclusion, our results laid new foundations for investigating the pathogenesis and diagnosis of cervical cancer.
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