Journal
GASTROENTEROLOGY CLINICS OF NORTH AMERICA
Volume 49, Issue 1, Pages 25-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.gtc.2019.09.001
Keywords
Non-alcoholic fatty liver disease (NAFLD); NASH; Genetic variation; PNPLA3; TM6SF2; GCKR; MBOAT7; HSD17B13
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Nonalcoholic fatty liver disease is strongly associated with obesity and the metabolic syndrome, but genetic factors also contribute to disease susceptibility, Human genetic studies have identified several common genetic variants contributing to nonalcoholic fatty liver disease initiation and progression. These findings have provided new insights into the pathogenesis of nonalcoholic fatty liver disease and opened up new avenues for the development of therapeutic interventions. In this review, we summarize the current state of knowledge about the genetic determinants of nonalcoholic fatty liver disease, focusing on the most robustly validated genetic risk factors and on recently discovered modifiers of disease progression.
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