4.3 Article

Thoughts on the evolution of Core Environmental Responses in yeasts

Journal

FUNGAL BIOLOGY
Volume 124, Issue 5, Pages 475-481

Publisher

ELSEVIER SCI LTD
DOI: 10.1016/j.funbio.2020.01.003

Keywords

Core stress responses; Evolution of anticipatory responses; Fungal memory; Fungal pathogens; Immune evasion; Stress responses

Categories

Funding

  1. Fundacao de Amparo Pesquisa do Estado de Sao Paulo [2018/20571-6]
  2. Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior [88881.289327/2018-01]
  3. UK Medical Research Council (MRC) [MR/M026663/1]
  4. MRC Centre for Medical Mycology, University of Exeter [MR/N006364/1]
  5. University of Aberdeen
  6. Wellcome Trust [097377]
  7. Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [18/20571-6] Funding Source: FAPESP
  8. MRC [MR/N006364/1, MR/N006364/2, MR/M026663/1] Funding Source: UKRI

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The model yeasts, Saccharomyces cerevisiae and Schizosaccharomyces pombe, display Core Environmental Responses (CERs) that include the induction of a core set of stress genes in response to diverse environmental stresses. CERs underlie the phenomenon of stress cross-protection, whereby exposure to one type of stress can provide protection against subsequent exposure to a second type of stress. CERs have probably arisen through the accumulation, over evolutionary time, of protective anticipatory responses (adaptive prediction). CERs have been observed in other evolutionarily divergent fungi but, interestingly, not in the pathogenic yeast, Candida albicans. We argue that this is because we have not looked in the right place. In response to specific host inputs, C. albicans does activate anticipatory responses that protect it against impending attack from the immune system. Therefore, we suggest that C. albicans has evolved a CER that reflects the environmental challenges it faces in host niches. (C) 2020 The Author(s). Published by Elsevier Ltd on behalf of British Mycological Society.

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