Journal
FOOD RESEARCH INTERNATIONAL
Volume 126, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.foodres.2019.108616
Keywords
Mangifera indica L.; Fruit by-products; Hansen solubility parameters; Pressurized-liquid extraction; LC-Q-TOF; GC-Q-TOF; High-resolution mass spectrometry; Antiproliferative activity; HT-29 cell line; CCD-18Co cell line
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Funding
- CSIC (Programa de Cooperacion Cientifica para el Desarrollo i-COOP + ) [COOPA20145]
- Ministry of Economy and Competitiveness
- [AGL2017-89417-R]
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A novel valorization strategy is proposed in this work for the sustainable utilization of a major mango processing waste (i.e. mango seed kernel, MSK), integrating green pressurized-liquid extraction (PLE), bioactive assays and comprehensive HRMS-based phytochemical characterization to obtain bioactive-rich fractions with high antioxidant capacity and antiproliferative activity against human colon cancer cells. Thus, a two steps PLE procedure was proposed to recover first the non-polar fraction (fatty acids and lipids) and second the polar fraction (polyphenols). Efficient selection of the most suitable solvent for the second PLE step (ethanol/ethyl acetate mixture) was based on the Hansen solubility parameters (HSP) approach. A comprehensive GC- and LC-Q-TOF-MS/MS profiling analysis allowed the complete characterization of the lipidic and phenolic fractions obtained under optimal condition (100% EtOH at 150 degrees C), demonstrating the abundance of oleic and stearic acids, as well as bioactive xanthones, phenolic acids, flavonoids, gallate derivatives and gallotannins. The obtained MSK-extract exhibited higher antiproliferative activity against human colon adenocarcinoma cell line HT-29 compared to traditional extraction procedures described in literature for MSK utilization (e.g. Soxhlet), demonstrating the great potential of the proposed valorization strategy as a valuable opportunity for mango processing industry to deliver a value-added product to the market with health promoting properties.
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