Journal
FOOD RESEARCH INTERNATIONAL
Volume 129, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.foodres.2019.108756
Keywords
Honey; Phenolic compounds; Anti-inflammatory effect; Cytokines; Raw 264.7; Lipopolysaccharides; Antioxidant activity
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Funding
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
- Coordenacao de Aperfeicoamento do Pessoal de Nivel Superior (CAPES) [001]
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The objective of this study was to investigate and quantify the composition phenolic, reducing capacity, the free radical scavenging activity, as well as, the anti-inflammatory effect evaluated against lipopolysaccharides-stimulated RAW264.7 macrophages through modulation of inflammatory mediators, in eight stingless bee honey types (Meliponinae) from southern Brazil. Stingless bee honey did not show to be cytotoxic at the tested concentrations (1-100 mu M) and also reduced nitric oxide and the secretion of the pro-inflammatory cytokine in the inflamed macrophages. Two honey samples showed the ability to increase the secretion of anti-inflammatory cytokine (interleukin-10), suggesting a significant anti-inflammatory effect. All these findings indicate that stingless bee honey could be an important source of natural compounds presenting anti-inflammatory and antioxidant effect, which could would provide health benefits when included in the diet.
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