Journal
FOOD CHEMISTRY
Volume 318, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2020.126358
Keywords
SO2 derivatives; Near-infrared fluorescent probe; Mitochondria-target; Fast-testing; Bioimaging
Funding
- National Natural Science Foundation of China, China [81872981]
- Key project of Shanghai 3-year plan, China [ZY(2018-2020)-CCCX-2001-04]
- National Scientific and Technological Major Special Project of China, China [2019ZX09201004-002]
- development fund for Shanghai talents, China [2018105]
- Youth Talent Sail Plan from the Shanghai Committee of Science and Technology, China [18YF1423600]
- Program of Shanghai Academic/Technology Research Leader, China [18XD1403700]
- Project of the Shanghai Municipal Commission of Health and Family Planning, China [2017YQ072, 201740152]
- Research Fund for the Doctoral Program of Shanghai, China [B201703]
- Xinglin Young Talent Program
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Overdoses of SO2 and its derivatives (SO32-/HSO3-) in food or organisms are harmful to health. To detect SO32-/HSO3-, a novel NIR fluorescent probe 1, based upon the intramolecular charge transfer (ICT) mechanism, was developed. This probe was easily synthesized, and gave noticeable colorimetric and linear fluorescence changes at 690 nm after reaction with sulfite from 3.13 to 200 mu M. Moreover, probe 1 displayed high sensitivity (LOD = 0.46 mu M), excellent selectivity (among 13 kinds of anions and 3 kinds of biothiols) and quick response (within 30 min) towards SO32-/HSO3-. The SO32-/HSO3- sensing mechanism was confirmed as the Michael addition reaction. Furthermore, the probe showed wide applications for measuring SO32-/HSO3- in real samples, including sugar, tap water, wine and traditional Chinese medicine. The probe could also be used to detect SO32-/HSO3- in mitochondria of HepG2 cells and zebrafish, which suggested potential application for monitoring SO2 derivatives in clinical diagnostics.
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