Journal
FOOD AND CHEMICAL TOXICOLOGY
Volume 137, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fct.2020.111126
Keywords
Syringic acid; Mixed micelles; Sustained release; Oral bioavailability; Carbon tetrachloride; Hepatoprotection
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Funding
- National Natural Science Foundation of China [81720108030, 81773695]
- National Twelfth Five-Year Plan for Science & Technology Support [2013BAD16B07-1]
- China Postdoctoral Science Foundation [2017M621658, 2017M621659]
- Program for Scientific Research Innovation Team in Colleges and Universities of Jiangsu Province [SJK2015-4]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
- Key Lab for Drug Delivery & Tissue Regeneration, Jiangsu Provincial Research Center for Medicinal Function Development of New Food Resources
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Syringic acid (SA), a natural polyphenol found in fruits and vegetables, is claimed to show notable hepatoprotection. Nevertheless, low solubility and bioavailability hamper the application of SA. This study aimed to investigate the potential of TPGS/F127/F68 mixed polymeric micelles as a sustained and liver-targeting nanocarrier for SA. Herein, the prepared SA-loaded TPGS/F127/F68 mixed polymeric micelles (SA-TPGS-Ms) were spherically-shaped and homogeneously-distributed nanoparticles with high entrapment efficiency (94.67 +/- 2.05%) and sustained release. Besides, in-vitro cell culture studies revealed that SA-TPGS-Ms substantially promoted cellular uptake with excellent biocompatibility. After oral administration, SA-TPGS-Ms demonstrated an increased bioavailability (2.3-fold) and delayed in-vivo elimination compared with the free SA. Furthermore, the alleviation of oxidative stress and amelioration of hepatic injury in CCl4-induced hepatotoxicity mice further demonstrated the excellent hepatoprotection of SA-TPGS-Ms. Collectively, SA-TPGS-Ms could be a promising nanocarrier for the utilization of SA in functional foods, with enhanced bioavailability and hepatoprotection.
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