Journal
FLUID PHASE EQUILIBRIA
Volume 505, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.fluid.2019.112341
Keywords
Aqueous two-phase systems; Aqueous biphasic systems; Biotechnology; Separation; Purification; Bioanalytics; Biomaterials; Bioprinting; Micropatterning
Funding
- FAPESP (Sao Paulo Research Foundation Brazil) [2014/16424-7]
- CNPq (National Council for Scientific and Technological Development, Brazil)
- CAPES (Coordination of Superior Level Staff Improvement, Brazil) [001]
- FCT/MOTES [POCI-01-0145-FEDER-007679, UID/CTM/50011/2019]
- FEDER, through COMPETE2020-Programa, Operacional Competitividade e Internacionalizacao (POCI) [POCI-01-0145-FEDER-030840]
- FEDER, through FCT/MCTES [POCI-01-0145-FEDER-030840]
Ask authors/readers for more resources
Aqueous two-phase systems (ATPS) have been mainly proposed as powerful platforms for the separation and purification of high-value biomolecules. However, after more than seven decades of research, ATPS are still a major academic curiosity, without their wide acceptance and implementation by industry, leading to the question whether ATPS should be mainly considered in downstream bioprocessing. Recently, due to their versatility and expansion of the Biotechnology and Material Science fields, these systems have been investigated in novel applications, such as in cellular micropatterning and bioprinting, microencapsulation, to mimic cells conditions, among others. This perspective aims to be a reflection on the current status of ATPS as separation platforms, while overviewing their applications, strengths and limitations. Novel applications, advantages and bottlenecks of ATPS are further discussed, indicating some directions on their use to create innovative industrial processes and commercial products. (C) 2019 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available