Journal
FISH & SHELLFISH IMMUNOLOGY
Volume 97, Issue -, Pages 493-499Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fsi.2019.12.029
Keywords
Grass carp; Ctenopharyngodon idella; CiGadd45aa; miR-731; Innate immunity; Apoptosis
Funding
- Central Public-interest Scientific Institution Basal Research Fund, CAFS [2017HY-XKQ0204]
- Earmarked Fund for China Agriculture Research System [CARS-45-03]
- National Natural Science Foundation of China [31802285]
- Project of Shanghai Engineering and Technology Centre for Promoting Ability [19DZ2284300]
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Ctenopharyngodon idella growth arrest and DNA damage-inducible 45aa (CiGadd45aa) is a member of the Gadd45 family of immune-related proteins in grass carp. There is increasing evidence that microRNAs (miRNAs) are involved in the regulation of inflammatory responses and apoptosis. However, little is known about the regulatory effects of miRNAs on CiGadd45aa expression in grass carp. In the present study, CiGadd45aa was identified as a target gene of miR-731 based on miRNA expression profiling and dual-luciferase reporter assay. Our study revealed that miR-731 targets CiGadd45aa and regulates the expression of proinflammatory factors, thereby regulating immune response in grass carp. In addition, CiGadd45aa and miR-731 were both found induced apoptosis. Hence, our findings provide a theoretical basis for exploring the molecular mechanism by which miR-731 regulates inflammation and apoptosis in grass carp.
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