Journal
FERTILITY AND STERILITY
Volume 113, Issue 3, Pages 478-488Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.fertnstert.2020.01.001
Keywords
Big data; epigenomics; genetic; genomics; male infertility; polymorphism
Categories
Funding
- National Institute of Health [5R01HD078641-05]
- Howard Hughes Medical Institute from the National Cancer Institute [P30CA042014]
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The complexity of male reproductive impairment has hampered characterization of the underlying genetic causes of male infertility. However, in the last 20 years, more powerful and affordable tools to interrogate the genetic and epigenetic determinants of male infertility have accelerated the number of new discoveries in the characterization of male infertility. With this explosion of new data, integration in a systems-based approach-including complete phenotypic information-to male infertility is imperative. We briefly review the current understanding of genetic and epigenetic causes of male infertility and how findings may be translated into a practical component for the diagnosis and treatment of male infertility. (C) 2020 by American Society for Reproductive Medicine.
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