Journal
FEMS YEAST RESEARCH
Volume 20, Issue 1, Pages -Publisher
OXFORD UNIV PRESS
DOI: 10.1093/femsyr/foaa005
Keywords
C. albicans; hyphae; morphogenesis; transcription factor(s); environmental signals
Funding
- NIAID NIH HHS [R15 AI137975] Funding Source: Medline
Ask authors/readers for more resources
Candida albicans is a multimorphic commensal organism and opportunistic fungal pathogen in humans. A morphological switch between unicellular budding yeast and multicellular filamentous hyphal growth forms plays a vital role in the virulence of C. albicans, and this transition is regulated in response to a range of environmental cues that are encountered in distinct host niches. Many unique transcription factors contribute to the transcriptional regulatory network that integrates these distinct environmental cues and determines which phenotypic state will be expressed. These hyphal morphogenesis regulators have been extensively investigated, and represent an increasingly important focus of study, due to their central role in controlling a key C. albicans virulence attribute. This review provides a succinct summary of the transcriptional regulatory factors and environmental signals that control hyphal morphogenesis in C. albicans.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available