Journal
FEBS LETTERS
Volume 594, Issue 16, Pages 2586-2597Publisher
WILEY
DOI: 10.1002/1873-3468.13758
Keywords
complement; evasion; Haemophilus influenzae; Moraxella catarrhalis; serum resistance
Funding
- Anna and Edwin Berger Foundation
- Swedish Medical Research Council (Vetenskapsradet) [2019-01053]
- Heart-Lung Foundation [20180401]
- Knut and Alice Wallenberg Foundation
- Swedish Research Council [2019-01053] Funding Source: Swedish Research Council
Ask authors/readers for more resources
All infective bacterial species need to conquer the innate immune system in order to colonize and survive in their hosts. The human respiratory pathogensHaemophilus influenzaeandMoraxella catarrhalisare no exceptions and have developed sophisticated mechanisms to evade complement-mediated killing. Both bacterial species carry lipooligosaccharides preventing complement attacks and attract and utilize host complement regulators C4b binding protein and factor H to inhibit the classical and alternative pathways of complement activation, respectively. In addition, the regulator of the terminal pathway of complement activation, vitronectin, is hijacked by both bacteria. An array of different outer membrane proteins (OMP) inH. influenzaeandM. catarrhalissimultaneously binds complement regulators, but also plasminogen. Several of the bacterial complement-binding proteins are important adhesins and contain highly conserved regions for interactions with the host. Thus, some of the OMP are viable targets for new therapeutics, including vaccines aimed at preventing respiratory tract diseases such as otitis media in children and exacerbations in patients suffering from chronic obstructive pulmonary disease.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available