Journal
EXPERT REVIEW OF ANTICANCER THERAPY
Volume 20, Issue 1, Pages 9-15Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14737140.2020.1705788
Keywords
FET PET; dendritic cells; checkpoint inhibitors; CAR-T cells; oncolytic virus immunotherapy
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Funding
- Wilhelm-Sander Stiftung, Germany
- Deutsche Forschungsgemeinschaft (DFG), Germany
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Introduction: Currently, immunotherapy using vaccination strategies or oncolytic virus approaches, cell-based immunotherapy, and the blockade of immune checkpoints are under evaluation in patients with brain cancer. Here we summarize clinically significant imaging findings such as treatment-related changes detected by advanced neuroimaging techniques following the most suitable immunotherapy options currently used in neuro-oncology. We, furthermore, provide an overview of how these advanced imaging techniques may help to overcome shortcomings of standard MRI in the assessment and follow-up of patients with brain cancer. Areas covered: The current literature on neuroimaging for immunotherapy in the field of brain tumors, with a focus on gliomas and brain metastases is summarized. Expert commentary: Data suggest that imaging parameters primarily derived from amino acid PET, diffusion- and perfusion-weighted MRI, or MR spectroscopy are particularly helpful for the evaluation of treatment response and provide valuable information for the differentiation of treatment-induced changes from actual brain tumor progression following various immunotherapy approaches.
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